作为助用户一臂之力的方法，本书介绍了以科学证据为基础的AHCC 的功能和用途。对AHCC在癌症预防和治疗方面的作用已经进行了重点研究，但AHCC 除了有抗癌作用外，因其免疫增强作用而
具有抗真菌，抗病毒，抗寄生等抗感染效果，此外它还显示出抗应激作用，增强抗癌药物疗效的作用，减轻免疫抑制等作用。另一方面，尽管详细作用机制尚未阐明，AHCC 通过修饰细胞间相互作用，抑制癌细胞浸润转移能力的效果已经得到认可。
AHCC®临床指南
全球有100多所大学和研究机构对AHCC®进行了研究，并发表了150多篇学术论文。
免疫 Immunity
感染症 Infectious Disease
癌症 Cancer
其他 Other
评测 Review
部分临床论文翻译
免疫 Immunity
| Autoimmune disease | Francisco Karkow, et al. AHCC® in Sjögren’s Disease: One Bold Therapeutic Hypothesis EC Microbiol. 2020; 16(1). | Clinical |
|---|---|---|
| Autoimmune disease | Zaure Zhaparkhanova, et al. Nutritional Immunotherapy in Autoimmune Thyroid Disease: Preliminary Results Endocrinology Quick Report. 2018; 2(50): 23-27. | Clinical |
| Immunomodulation | Jean‑François Mallet, et al. Eur J Nutr. 2016; 55(1): 139-46. | Basic |
| Immunomodulation | Loretta Olamigoke, et al. Evid Based Complement Alternat Med. 2015; 2015: 508746. | Basic |
| Immunomodulation | Jun Takanari, et al. J Evid Based Complementary Altern Med. 2015; 20(1): 28-34. | Clinical |
| Immunomodulation | Mari Kogiso, et al. Active Hexose Correlated Compound and T Cell Response in Hind – Limb – Unloaded BALB/c Mice Int J Surg. 2015; 2(5): 32-38. | Basic |
| Immunomodulation | Abdelali Daddaoua, et al. Food Chem. 2013; 136(3-4): 1288-95. | Basic |
| Immunomodulation | Tominori Kimura, et al. Stabilization of human interferon-α1 mRNA by its antisense RNA Cell Mol Life Sci. 2013; 70(8): 1451-67. | Basic |
| Immunomodulation | Won-Woo Lee, et al. Cell Immunol. 2012; 275(1-2): 19-23. | Basic |
| Immunomodulation | Zhinan Yin, et al. Hum Immunol. 2010; 71(12): 1187-90. | Clinical |
| Immunomodulation | Naoyoshi Terakawa, et al. Nutr Cancer. 2008; 60(5): 643-51. | Clinical |
| Immunomodulation | Mari Kogiso, et al. Active Hexose Correlated Compound and T Cell Response in Hind-Limb-Unloaded BALB/c Mice Int J Surg. 2015; 2(5): 32-38. | Basic |
| Immunomodulation | Roghayeh Shahbazi, et al. Int. J. Mol. Sci. 2023, 24(19), 14610 | Basic |
| Peritonitis | Katie M Love, et al. J Trauma Acute Care Surg. 2013; 74(6): 1411-8. | Basic |
| Synbiotics | Abeed H Chowdhury, et al. Nutrients. 2019; 11(10): 2470. | Clinical |
| Synbiotics, colitis | Borja Ocón, et al. Eur J Nutr. 2013; 52(2): 457-66. | Basic |
| Adenocarcinoma (pancreatic cancer, lung cancer, colon cancer） | Andrea Del Buono, et al. World Cancer Research Journal. 2016; 3 (1): e652. | Clinical |
| Liver cancer | Zhiyun Cao, et al. Nutr Res Pract. 2015; 9(2): 129-36. | Basic |
感染症 Infectious Disease
| HPV | Victoria L Gau, et al. J Voice. 2022; 36(4): 441-442. | Editorial |
|---|---|---|
| HPV | Judith A Smith, et al. AHCC® Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections Front Oncol. 2022; 12: 881902. | Clinical |
| HPV | Manami Misu, et al. Clinical Effects of AHCC® on High-risk Human Papillomavirus Infection and Secretory IgA Japanese Pharmacology & Therapeutics. 2019; 47(11): 1921-1928. | Clinical |
| HPV | Judith A Smith, et al. Front Oncol. 2019; 9: 173. | Clinical |
| COVID-19 | Takeshi Katsuki, et al. COVID-19 Pathology and Countermeasures ─Necessity of Severity Prevention Self-care─ Journal of Japan Health Medicine Association, 29(2): 142-152, 2020 | Review |
| COVID-19 | Ali A. Rabaan, et al. Ann Clin Microbiol Antimicrob. 2020; 19(1): 40 | Review |
| Influenza | Brooke E Roman, et al. Nutr Res. 2013; 33(1): 12-7. | Clinical |
| Influenza | Shoko Nogusa, et al. Nutr Res. 2009; 29(2): 139-43. | Basic |
| Trichinella | Beatriz López-Cauce, et al. Biomed Pharmacother. 2022; 150: 112937. | Basic |
| P. aeruginosa | Mireia Tena-Garitaonaindia, et al. Front Microbiol. 2022; 13: 814448. | Basic |
| Influenza, avian influenza, K. pneumoniae, C. albicans, P. aeruginosa, MRSA | Barry W Ritz Nutr Rev. 2008; 66(9): 526-31. | Basic |
| Leishmaniasis | María-Dolores Tabar, et al. Leishmaniosis in a cat with chronic diarrhea as the only clinical manifestation J Vet Intern Med. 2022; 36(2): 753-757. | Veterinary |
| Leishmaniasis | María Auxiliadora Dea-Ayuela, et al. Nucleotides and AHCC Enhance Th1 Responses In Vitro in Leishmania-Stimulated/Infected Murine Cells Molecules. 2020; 25(17): 3918. | Basic |
| Leishmaniasis | Rodolfo Oliveira Leal, et al. JFMS Open Rep. 2018; 4(2): 2055116918811374. | Veterinary |
| Leishmaniasis | Sergi Segarra, et al. Parasit Vectors. 2018; 11(1): 103. | Veterinary |
| Leishmaniasis | Sergi Segarra, et al. Vet Parasitol. 2017; 239: 50-56. | Veterinary |
| Leishmaniasis | Sergi Segarra. Nutritional Modulation of the Immune Response Mediated by Nucleotides in Canine Leishmaniosis Microorganisms. 2021; 9(12): 2601. | Veterinary |
| Lyme disease | John Salerno, et al. A Pilot Open-Label Study Assessing the Effects of AHCC® Supplementation on Lyme Disease Patients Bioactive Compounds in Health and Disease. 2019; 2(11): 221-229. | Clinical |
| MAC lung disease | Masaki Fujita, et al. J Nutr Disorders Ther. 2015; 5: 4. | Basic |
| West Nile fever | Shuhui Wang, et al. J Nutr. 2009; 139(3): 598-602. | Basic |
| Postoperative complication, K. pneumoniae | Hernan Aviles, et al. Am J Surg. 2008; 195(4): 537-45. | Basic |
| Chlamydia | Tesfaye Belay, et al. Infect Immun. 2021; 89(5): e00786-20. | Basic |
| Chlamydia | Tesfaye Belay, et al. J Nutr Med Diet Care. 2015; 1(1): JNMDC-1-006. | Basic |
| Aspergillosis | Alba Pérez-Cantero, et al. Pharmaceutics. 2019; 11(9): 456. | Basic |
| Hepatitis C | Sayam Thaiudom, et al. The Medical News (Thailand). 2010; 325: 13-16. | Clinical |
癌症 Cancer
| Pancreatic cancer | Hiroaki Yanagimoto, et al. Nutr Cancer. 2023; 75(1): 236-246. | Clinical |
|---|---|---|
| Pancreatic cancer | Daisuke Hashimoto, et al. Trials. 2022; 23(1): 135. | Protocol |
| Pancreatic cancer | Yasuhiro Kuramitsu, et al. Analysis of Cancer-Related Proteins Using Electrophoresis and Its Clinical Application Electrophoresis Letters. 2021; 65(2): 23-27. | Review |
| Pancreatic cancer | Shajedul Islam, et al. Oncol Lett. 2021; 22(3): 654. | Basic |
| Pancreatic cancer | Daisuke Hashimoto, et al. Surg Today. 2021; 51(11): 1872-1876. | Clinical |
| Pancreatic cancer | Anarkhuu Bold-Erdene, et al. Diagnosis. 2018; 83(3): 56-60. | Clinical |
| Pancreatic cancer | Keisuke Kuhara, et al. Anticancer Res. 2018; 38(11): 6107-6111. | Basic |
| Pancreatic cancer | Hiroaki Yanagimoto, et al. Nutr Cancer. 2016; 68(2): 234-40. | Clinical |
| Pancreatic cancer | Masayuki Tokunaga, et al. Anticancer Res. 2015; 35(11): 6063-7. | Basic |
| Pancreatic cancer | Junya Nawata, et al. Anticancer Res. 2014; 34(9): 4807-11. | Basic |
| Pancreatic cancer | Shigeyuki Suenaga, et al. Anticancer Res. 2014; 34(1): 141-6. | Basic |
| Liver cancer | Toshiya Kamiyama, et al. Integr Cancer Ther. 2022; 21: 15347354211073066. | Clinical |
| Liver cancer | Zhiyun Cao, et al. Nutr Res Pract. 2015; 9(2): 129-36. | Basic |
| Breast cancer | Koji Wakame, et al. Integr Cancer Sci Ther. 2017; 4(1). | Clinical |
| Breast cancer | Mehran Haidari, et al. Life Sci. 2013; 93(25-26): 994-1003. | Basic |
| Breast cancer | Sho Hangai, et al. J Altern Complement Med. 2013; 19(11): 905-10. | Clinical |
| Breast cancer | Yoichi Matsui, et al. Retrospective Study in Breast Cancer Patients Supplemented with AHCC Inte J Integr Oncol. 2009; 3(2): 12-16. | Clinical |
| Adverse effect | Daisuke Nakamoto, et al. Intern J Clin Med. 2012; 3: 361-367. | Basic |
| Adverse effect | Kota Shigama, et al. J Exp Ther Oncol. 2009; 8(1): 43-51. | Basic |
| Adverse effect | Buxiang Sun, et al. Cancer Epidemiol. 2009; 33(3-4): 293-9. | Basic |
| Ovarian cancer | Jin Young Choia, et al. Nutr Cancer. 2018; 70(1): 109-115. | Basic |
| Ovarian cancer | Wineeya Suknikhom, et al. Asian Pac J Cancer Prev. 2017; 18(3): 633-638. | Clinical |
| Prostate cancer | Yoshiteru Sumiyoshi, et al. Jpn J Clin Oncol. 2010; 40(10): 967-72. | Clinical |
| Prostate cancer | Jeffrey Turner, et al. Anticancer Drugs. 2009; 20(3): 215-6. | Clinical |
| Colon cancer | Francesca Paganelli, et al. Pharmaceuticals. 2021; 14(12): 1325. | Basic |
| Colon cancer | Maiko Takahashi, et al. J Clin Biochem Nutr. 2019; 65(3): 203-208. | Basic |
| Immune checkpoint inhibitors, colon cancer | Hong-Jai Park, et al. Front Immunol. 2022; 13: 875872. | Basic |
| Lung cancer | Reiki Ishizuka, et al. Pers Med Univers. 2012; 1(1): 39-44. | Clinical |
| Lung cancer, breast cancer | Reiki Ishizuka, et al. International Journal of Integrative Medicine. 2010; 2(1): 98-111. | Clinical |
| Drug interaction, breast cancer | Lata Mathew, et al. Integr Cancer Ther. 2017; 16(3): 300-307. | Basic |
| Drug interaction, ovarian cancer | Rodney J Hunter, et al. Int J Appl Res Nat Prod. 2011; 4(3): 6-14. | Basic |
| Adenocarcinoma (pancreatic cancer, lung cancer, colon cancer） | Andrea Del Buono, et al. World Cancer Research Journal. 2016; 3 (1): e652. | Clinical |
| Gastric cancer, colon cancer | Yusai Kawaguchi Natural Medicine Journal. 2009; 1(1). | Clinical |
| Leukemia | Kavin Fatehchand, et al. PLoS One. 2017; 12(7): e0181729. | Basic |
| Head and neck cancer | Dillip Kumar Parida, et al. Intern J Clin Med. 2011; 2, 588-592. | Clinical |
| Salivary gland cancer | Tamer A Badawi, et al. Cairo Dental Journal. 2012; 28(1): 485-490. | Basic |
| Colon cancer, pancreatic cancer, lung cancer, ovarian cancer | Toshinori Ito, et al. Nutr Cancer. 2014; 66(3): 377-82. | Clinical |
| Cancer stem cell, breast cancer | Émilie A Graham, et al. Cancer Biol Ther. 2017; 18(10): 765-774. | Basic |
| Apoptosis, cancer stem cell | Bruna Corradetti, et al. Integr Cancer Ther. 2019; 18: 1534735419866908. | Basic |
| Malignant melanoma | Rosa Mistica Ignacio, et al. Cytokine. 2015; 76(2): 131-137. | Basic |
其他 Other
| Goiter | Zaure Zhaparkhanova, et al. J Clin Med Kaz. 2021; 18(2): 66-71. | Clinical |
|---|---|---|
| Hepatitis | Yoshito Tanaka, et al. Nitric Oxide. 2014; 40: 75-86. | Basic |
| Hepatitis | Kosuke Matsui, et al. Eur Surg Res. 2011; 47(4): 274-83. | Basic |
| Hepatitis | Tadayoshi Okumura, et al. Journal of the Japanese Society of Food Engineering. 2010; 30(3): 100-106. | Basic |
| Drug interaction | Rachel E. Carlson, et al. IJNF. 2018; 4(5): 32-36. | Basic |
| Drug interaction | Larry W Coffer, et al. J Integr Oncol. 2015; doi:10.4172/2329-6771.1000142. | Basic |
| Drug interaction | Claire M Mach, et al. J Soc Integr Oncol. 2008; 6(3): 105-9. | Basic |
| Sepsis | Marie-Francoise Doursout, et al. Active hexose correlated compound modulates LPS-induced hypotension and gut injury in rats Int Immunopharmacol. 2016; 39: 280-286. | Basic |
| Colitis | Cristina Mascaraque, et al. Active hexose correlated compound exerts therapeutic effects in lymphocyte driven colitis Mol Nutr Food Res. 2014; 58(12): 2379-82. | Basic |
| Autonomic nerve | Jun Takanari, et al. Effects of AHCC® on Immune and Stress Responses in Healthy Individuals J Evid Based Integr Med. 2018; 23: 2156587218756511. | Clinical |
| Infantile epilepsy | Natalia V Mikhailichenko, et al. FFHD. 2019; 9(3): 145-156. | Clinical |
| Muscle atrophy | Young-Ju Song, et al. AHCC Supplementation Attenuates Muscle Atrophy via Akt Activation in Hindlimb-suspended Rat Biotechnol Bioprocess Eng. 2019; 24: 476-482. | Basic |
| Ischemia-reperfusion injury | Yosuke Ueyama, et al. J Surg Res. 2019; 243: 265-273. | Basic |
| Liver disorder | Richi Nakatake, et al. FFHD. 2016; 6(11): 702-717. | Basic |
| Longevity (nematode) | Tetsuya Okuyama, et al. FFHD. 2013; 3(6):166-182. | Basic |
| Gene expression profiling | Koji Wakame, et al. Integr Mol Med. 2016; 3(3): 739-744. | Basic |
| Alcoholic fatty liver | Hyangkyoung Kim, et al. Effect of Active Hexose Correlated Compound (AHCC) in Alcohol-Induced Liver Enzyme Elevation J Nutr Sci Vitaminol. 2014; 60(5): 348-56. | Clinical |
Hajime Fujii, et al. Genotoxicity and subchronic toxicity evaluation of Active Hexose Correlated Compound (AHCC) Regul Toxicol Pharmacol. 2011; 59(2): 237-50. | Basic |
评测 Review
| Complementary therapy | Takehito Miura Unwellness and Functional Foods: The Expected Role of Pharmacies J Jpn Mibyou Assoc. 2022; 28(2): 43-48. | Review |
|---|---|---|
| Complementary therapy | Jun-Young Choi Complementary Therapy for Improvement of Quality of Life in Cancer Patients J Korean Med Assoc. 2008; 51(5): 435-448. | Review |
| Immunity | Min Sun Shin, et al. J Immunol Res. 2019; 2019: 3758576 | Review |
| Immunity | Hiroshi Nishioka, et al. Potentiating action of AHCC on natural immunity Medical Science Digest. 2009; 35(6): 241-244. | Review |
| Prostate cancer | Philippa J Cheetham, et al. Diet and prostate cancer – a holistic approach to management Arch Esp Urol. 2011; 64(8): 720-34. | Review |
| Infection, COVID-19 | Francesco Di Pierro, et al. Minerva Gastroenterol Dietol. 2020; 66(2): 172-176. | Review |
| Allergic disease, autoimmune disease, lifestyle disease | Manami Misu, et al. Various functions of AHCC® – Case Report New Food Industry. 2017; 59(2): 14-21. | Review |
| Pet animal | Yutaka Horiuchi, et al. Complementary and Alternative Medicine and AHCC®, GCP® in Companion Animals Companion Animal Practice. 2012; 4: 53-57. | Veterinary |
| Pet animal | Takashi Nishizawa, et al. Companion Animal Practice. 2011 Apr. | Veterinary |
| Pet animal | Mamoru Onuma, et al. The supplementation therapy of caine dermatology in my hospital Japanese Journal of Small Animal Practice. 2008; 27(6): 340-346. | Veterinary |
Mikio Nishizawa, et al. Assessment of anti-inflammatory effects of Japanese Kampo medicine versus functional foods FFHD. 2019; 9(2): 79-91. | Review | |
Hiroshi Nishioka, et al. Various functions of a standardized extract of cultured Lentinula edodes mycelia (AHCC®) Medical Science Digest. 2019; 45(2): 127-130. | Review | |
Koji Wakame Research and functional development of basidiomycete culture extracts Agricultural biotechnology. 2017; 1(4): 438-442. | Review | |
Robert M Hackman, et al. Forecasting Nutrition Research in 2020 J Am Coll Nutr. 2014; 33(4): 340-6. | Review | |
Catherine Ulbricht, et al. J Diet Suppl. 2013; 10(3): 264-308. | Review | |
Yasuo Kamiyama AHCC: basic and clinical research Journal of the society tropical resources technologists. 2011; 27(1): 1-8. | Review | |
Shinil K Shah, et al. J Parenter Enteral Nutr. 2011; 35(4): 449-58. | Review | |
Barry W Ritz Active Hexose Correlated Compound (AHCC) and Immune Outcomes in Humans: A Review Natural Medicine Journal. 2011; 3(1): 3-7. | Review | |
Takehito Miura, et al. Basic and Clinical Studies on Active Hexose Correlated Compound Biotechnology in Functional Foods and Nutraceuticals. 2010: 51-58. | Book | |
Takehito Miura, et al. Basic and Clinical Studies on AHCC —Recent Topics— Japanese Journal of Complementary and Alternative Medicine. 2009; 6(1): 1-7. | Review | |
Kentaro Kitadate Augmentation of Anticancer Activity and Attenuation of Side Effect by AHCC FOOD Style 21. 2008; 132: 69-72. | Basic |
部分临床论文翻译
AHCC 和 GCP 临床研究成果汇编
本文收集了AHCC和GCP的多个临床研究结果，展示了它们在不同癌症和健康问题中的有效性。
1. 肝细胞癌手术后预后改善
日本关西医科大学外科 上山泰男教授
Journal of Hepatology 37:78-86, 2002
肝细胞癌手术后使用 AHCC 的患者比对照组有明显更长的无复发期，并提高了生存率。手术后9年，AHCC组生存率达到50%，而对照组不到30%。
2. 功能食品与肝癌治疗
美国加州大学消化科 Nathan M. Bass 教授
Journal of Hepatology 37:147-150, 2002
试验表明，AHCC 显著提高了患者的生存率，延长了无复发期。功能食品需要严格的科学试验来验证其效果。
3. AHCC 对 NK 细胞活性的提高
美国 Lexington 自然健康中心 James T. Belanger 主任医师
Townsend Letter for Doctors & Patients, 2005
34 名癌症患者分 4 组进行试验，服用 AHCC 后，NK 细胞活性平均提高 249%，显著优于其他保健食品。
4. AHCC 对人宫颈癌移植瘤的抑制效果
美国德州大学和爱德森癌症中心
ISIM 国际统合医学会, 2011
AHCC 能预防或延迟 HPV 感染引起的人宫颈癌移植瘤的生长，表现出良好的抑制效果。
5. AHCC 对老年人免疫功能的增强
美国耶鲁大学 医学部 尹芝南教授
第 16 届 AHCC/GCP 国际研究会, 2008
服用 AHCC 可增强老年人的 CD4+ 和 CD8+ T 细胞的免疫反应，且在结束服用 30 天后仍然保持作用。
6. AHCC 对化疗毒副作用的减轻
日本大阪大学院医学系研究科 井仓技教授
临床试验结果
在化疗过程中并用 AHCC，显著减少了白血球减少、中性粒细胞减少等毒副作用，并改善了患者的生活质量。
7. AHCC 对胰脏癌和胆管癌的化疗效果
日本关西医科大学 外科 柳本泰明教授
临床试验结果
与对照组相比，服用 AHCC 的患者在贫血和炎症反应方面有明显改善，同时减少了化疗引起的味觉异常。
8. AHCC 对健康志愿者免疫功能的改善
日本关西医科大学 外科 上山泰男教授
《癌症与营养》, 2008
通过双盲实验，服用 AHCC 的健康志愿者外周血免疫参数显著改善，特别是 CD4+ 和 NK 细胞活性有明显增强。
9. AHCC 对胃癌及肠癌患者的免疫功能改善
日本关西医科大学 外科 上山泰男教授
《自然医学杂志》, 2009
使用 AHCC 联合标准化疗后，胃癌和肠癌患者的免疫监测功能显著提升，特别是对于中期癌症患者效果更为显著。
10. GCP 对前列腺癌的治疗效果
哥伦比亚大学 Presbyterian 医疗中心泌尿外科 Aaron E. Katz 教授
The Journal of Alternative and Complementary Medicine 8(4):493-497, 2002
患者服用 GCP 后，PSA 显著下降，未发现癌细胞，且无毒副作用，显示出显著治疗效果。
11. GCP 对糖尿病性网膜症的激素调节和抗氧化效果
韩国延世大学 Sun Yoon 教授
Journal of Medicinal Food 8(1):1-7, 2005
GCP 对并发糖尿病性网膜症的更年期女性具有明显的激素调节效果，并提高了抗氧化酶的活性。
12. AHCC 和 GCP 对晚期肺癌和乳癌患者的效果
日本田岛医院 石塚玲器教授
个性化 EBM 与 AHCC 和 GCP 长期使用观察, 11年
在 11 年的观察中，晚期肺癌和乳癌患者服用 AHCC 和 GCP 后，显著延长了生存时间并提高了生活质量。