Psychological stress | Akihiro Ishida, et al. Influence of Chewing Gummy Jelly Containing Aroma Compound on Psychological Stress and Autonomic Nervous System Activity: A Randomized Crossover Trial Bull Tokyo Dent Coll. 2023. | Clinical |
Sarcopenia | Li-Ning Peng, et al. Clinical efficacy of oligonol® supplementation on metabolism and muscle health in middle-aged and older adults: A double-blinded randomized controlled trial Arch Gerontol Geriatr. 2022; 103: 104784. | Clinical |
Sarcopenia | Yun-Ching Chang, et al. Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality Mol Nutr Food Res. 2019; 63(10): e1801102. | Basic |
Opportunistic infection, Candida | Mie Kojima, et al. Usefulness of Aroma Candy in the Oral Care of Residents of Special Elderly Nursing Homes The Japanese Journal of Dysphagia Rehabilitation. 2021; 25(2): 120-128 | Clinical |
Opportunistic infection, Candida | Yoichi Nakagawa, et al. Anti-Candida effectiveness of a candy containing citral, cinnamaldehyde, oligonol, and capric acid for oral candidiasis Oral Therapeutics and Pharmacology. 2018; 37(3): 101-107. | Clinical |
Opportunistic infection, Candida | Kazumi Hayama, et al. Inhibitory effects of several saturated fatty acids and their related fatty alcohols on the growth of Candida albicans Drug Discov Ther. 2015; 9(6): 386-90. | Basic |
Opportunistic infection, Candida | Kazumi Hayama, et al. Development of a new aroma candy for maintenance of the oral health Med Mycol Res. 2015; 6(1): 3-9. | Clinical |
Opportunistic infection, Candida | Motofumi Suzuki, et al. The Effects of an Aroma Candy on Oral Candida albicans Colony-forming Units (CFU) and Oral Hygiene States in Healthy Elderly Carrying Candida albicans Medical Mycology Journal. 2015; 56: J31-J40. | Clinical |
Opportunistic infection, Candida | Kazumi Hayama, et al. Anti-Candida Activity of Aroma Candy and Its Protective Activity Against Murine Oral Candidiasis Medical Mycology Journal. 2015; 56: J23-J29. | Basic |
Opportunistic infection, Candida | Kazumi Hayama, et al. Therapeutic Effect of Oligonol, a Low-molecular Polyphenol Formulation Derived from Lychee Fruits on Murine Oral Candidiasis Japanese Journal of Medical Mycology. 2010; 51(3): 137–142. | Basic |
Betanodavirus | Toru Ichinose, et al. Evaluation of antiviral activity of Oligonol, an extract of Litchi chinensis, against betanodavirus Drug Discov Ther. 2013; 7(6): 254-60. | Basic |
Influenza | Noboru Uchide, et al. Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications Molecules. 2011; 16(3): 2032-52. | Basic |
Influenza | Leila Gangehei, et al. Oligonol a low molecular weight polyphenol of lychee fruit extract inhibits proliferation of influenza virus by blocking reactive oxygen species-dependent ERK phosphorylation Phytomedicine. 2010; 17(13): 1047-56. | Basic |
Dry mouth | Jeong Hun Kim, et al. Effects of oligonol on the submandibular gland in ovariectomized rats Biomed Pharmacother. 2021;141:111897. | Basic |
Retinal protecion | Jun Kisugi, et al. Suppression of N-Methyl-N-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation ABC. 2014; 4(2), 138-147. | Basic |
Liver fibrosis | Jihyun Kim, et al. Integrative Transcriptomic Analysis Reveals Upregulated Apoptotic Signaling in Wound-Healing Pathway in Rat Liver Fibrosis Models Antioxidants. 2023; 12(8): 1588. | Basic |
Liver fibrosis | Changyong Lee, et al. Protective Effect of Oligonol on Dimethylnitrosamine-Induced Liver Fibrosis in Rats via the JNK/NF-κB and PI3K/Akt/Nrf2 Signaling Pathways Antioxidants. 2021; 10(3): 366. | Basic |
Immunity | Jeong Beom Lee, et al. Oligonol Supplementation Affects Leukocyte and Immune Cell Counts after Heat Loading in Humans Nutrients. 2014; 6(6): 2466-77. | Clinical |
Colitis | K-J Kim, et al. Oligonol prevented the relapse of dextran sulfate sodium-ulcerative colitis through enhancing NRF2-mediated antioxidative defense mechanism J Physiol Pharmacol. 2018; 69(3). | Basic |
Colitis | Hye-Won Yum, et al. Oligonol Inhibits Dextran Sulfate Sodium-Induced Colitis and Colonic Adenoma Formation in Mice Antioxid Redox Signal. 2013; 19(2): 102-14. | Basic |
Prostatitis | İlhan Öztekin, et al. Therapeutic Effects of Oligonol, Acupuncture, and Quantum Light Therapy in Chronic Nonbacterial Prostatitis Evid Based Complement Alternat Med. 2015; 2015: 687196. | Basic |
Prostatitis | Hakan Akdere, et al. Analgesic Effects of Oligonol, Acupuncture and Quantum Light Therapy on Chronic Nonbacterial Prostatitis Iran Red Crescent Med J. 2015; 17(4): e26006. | Basic |
Hepatitis | Jeonghyeon Bak, et al. Oligonol Ameliorates CCl4-Induced Liver Injury in Rats via the NK-Kappa B and MAPK Signaling Pathways Oxid Med Cell Longev. 2016; 2016: 3935841. | Basic |
Esophagitis, gastric ulcer | Seong-Soo Roh, et al. Low-Molecular-Weight Oligonol, a Polyphenol Derived from Lychee Fruit, Attenuates Experimental Reflux Esophagitis and HCl/Ethanol-Induced Gastric Ulcer J Med Food. 2017; 20(12): 1214-1221. | Basic |
Air pollution | Takumi Shibukawa, et al. Absorption of Nitrogen Dioxide by the Polyphenol Solution Kagaku kogaku ronbunshu. 2011; 37(2): 162-166. | Basic |
Sexual performance | Koji Wakame, et al. Attempt to develop a sexual function-improving drink containing various natural food ingredients FOOD STYLE 21. 2011; 165: 41-43. | Clinical |
Neurodegenerative disease | Jae Hyun Ahn, et al. Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell Nutr Res Pract. 2015; 9(2): 123-8. | Basic |
Anti-oxidation | Katsuhiko Suzuki, et al. Functional Analyses of Oligonol by Novel Neutrophil Activity Measurement System Japanese Journal of Complementary and Alternative Medicine. 2013; 10(1): 59-62. | Basic |
Anti-inflammation | Naeun Lee, et al. Oligonol, a lychee fruit-derived low-molecular form of polyphenol mixture, suppresses inflammatory cytokine production from human monocytes Hum Immunol. 2016; 77(6): 512-5. | Basic |
Supercooling | Tsutomu Uchida, et al. Effect of Polyphenols on the Ice-Nucleation Activity of Ultrafine Bubbles Nanomaterials. 2023; 13(1): 205. | Basic |
Supercooling | Seizo Fujikawa, et al. Supercooling-Promoting (Anti-ice Nucleation) Substances Survival Strategies in Extreme Cold and Desiccation. 2018: 289-320. | Book |
Supercooling | Seizo Fujikawa, et al. Current Research on Supercooling Accelerators Functions and Applications of Antifreeze Protein. 2018: 180-190. | Book |
Supercooling | Toshie Koyama, et al. Anti-ice nucleating activity of polyphenol compounds against silver iodide Cryobiology. 2014; 69(2): 223-8. | Basic |
Supercooling | Chikako Kuwabara, et al. Analysis of supercooling activity of tannin-related polyphenols Cryobiology. 2013; 67(1): 40-9. | Review |
Alzheimer’s disease | Xiao Chen, et al. Flavanol-rich lychee fruit extract substantially reduces progressive cognitive and molecular deficits in a triple-transgenic animal model of Alzheimer disease Nutr Neurosci. 2019; 1-15. | Basic |
Alzheimer’s disease | Yoon Young Choi, et al. Oligonol improves memory and cognition under an amyloid β25-35-induced Alzheimer’s mouse model Nutr Res. 2014; 34(7): 595-603. | Basic |
Cognitive function | Takuya Sakurai, et al. Oligomerized lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells Br J Nutr. 2013; 110(9): 1549-58. | Basic |
Ovarian cancer | Miseon Kim, et al. Oligonol, a Low Molecular Weight Polyphenol, Enhances Apoptotic Cell Death in Ovarian Cancer Cells via Suppressing NF-κB Activation Nutr Cancer. 2019; 71(1): 141-148. | Basic |
Malignant melanoma, lung metastasis | Sung-Jae Lee, et al. Inhibition of Lung Metastasis in Mice by Oligonol Phytother Res. 2009; 23(7): 1043-6. | Basic |
Action mechanism | Ryota Yamanishi, et al. The Anti-inflammatory Effects of Flavanol-rich Lychee Fruit Extract in Rat Hepatocytes PLoS One. 2014; 9(4): e93818. | Basic |
Safety | Kentaro Kitadate, et al. Thirteen-week oral dose toxicity study of Oligonol containing oligomerized polyphenols extracted from lychee and green tea Regul Toxicol Pharmacol. 2014; 68(1): 140-6. | Basic |
Safety | Mahesh Thirunavukkarasu, et al. Safety of oligonol, a highly bioavailable lychee-derived polyphenolic antioxidant, on liver, kidney and heart function in rats Toxicol Mech Methods. 2012; 22(7): 555-9. | Basic |
Safety | Hajime Fujii, et al. Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts Food Chem Toxicol. 2008; 46(12): 3553-62. | Basic |